Kauffman C A
Department of Internal Medicine, Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48105, USA.
Clin Infect Dis. 1996 May;22 Suppl 2:S148-53. doi: 10.1093/clinids/22.supplement_2.s148.
The addition of itraconazole and fluconazole to the antifungal armamentarium has resulted in less toxic, easily administered therapy for both endemic and opportunistic mycoses. Itraconazole has become the treatment of choice for most patients with mild-to-moderate histoplasmosis, blastomycosis, and sporotrichosis. Coccidioidomycosis is effectively treated with either itraconazole or fluconazole; fluconazole has become the drug of choice for the treatment of coccidioidal meningitis. In several large cooperative trials, fluconazole has been shown to have a useful role in the treatment of patients with candidemia, localized forms of mucocutaneous and visceral candidiasis, and cryptococcal meningitis.
将伊曲康唑和氟康唑添加到抗真菌药物库中，已为地方性和机会性真菌病带来了毒性较小、易于给药的治疗方法。伊曲康唑已成为大多数轻至中度组织胞浆菌病、芽生菌病和孢子丝菌病患者的首选治疗药物。球孢子菌病用伊曲康唑或氟康唑均可有效治疗；氟康唑已成为治疗球孢子菌性脑膜炎的首选药物。在几项大型合作试验中，氟康唑已被证明在治疗念珠菌血症、局部形式的黏膜皮肤和内脏念珠菌病以及隐球菌性脑膜炎患者方面具有有益作用。
