Bartlett E J, Brodie J D, Simkowitz P, Dewey S L, Rusinek H, Volkow N D, Wolf A P, Smith G, Wolkin A, Cancro R
Department of Psychiatry, New York University Medical Center, NY 10016, USA.
Psychiatry Res. 1996 Mar 29;60(2-3):91-9. doi: 10.1016/0165-1781(96)02711-4.
Positron emission tomography and the fluorodeoxyglucose method were used to measure regional brain metabolism before and 2 h after haloperidol (5 mg, i.m.) in 11 young normal men. These data were compared with measures obtained from nine previously studied normal men who had received no drug intervention. Although a previously published study had demonstrated significantly decreased metabolism in whole brain, neocortex, limbic cortex, thalamus, and caudate nucleus 12 h after a 5-mg dose of haloperidol, the present 2-h study did not show significant metabolic changes despite the fact that significant extrapyramidal effects occurred. Taken together, these studies demonstrate differences in the temporal organization of behavioral and metabolic responses to haloperidol challenge.
采用正电子发射断层扫描和氟脱氧葡萄糖法，对11名年轻正常男性在肌肉注射5毫克氟哌啶醇前及注射后2小时的局部脑代谢进行了测量。这些数据与9名先前研究的未接受药物干预的正常男性所获得的测量结果进行了比较。尽管先前发表的一项研究表明，服用5毫克氟哌啶醇12小时后，全脑、新皮质、边缘皮质、丘脑和尾状核的代谢显著降低，但在本项2小时的研究中，尽管出现了明显的锥体外系效应，却未显示出显著的代谢变化。综合来看，这些研究表明了对氟哌啶醇激发的行为和代谢反应在时间组织上存在差异。
