Bartlett E J, Brodie J D, Simkowitz P, Dewey S L, Rusinek H, Wolf A P, Fowler J S, Volkow N D, Smith G, Wolkin A
Department of Psychiatry, New York University Medical Center, NY 10016.
Am J Psychiatry. 1994 May;151(5):681-6. doi: 10.1176/ajp.151.5.681.
Positron emission tomography and the fluorodeoxyglucose (FDG) method were used to determine the brain's metabolic response to neuroleptic challenge in a normal, disease-free state.
FDG measurements were obtained before and 12 hours after administration of 5 mg of haloperidol to 12 young normal men. These values were compared with test-retest FDG measures obtained from nine normal male control subjects who received no drug intervention.
After haloperidol administration, the haloperidol subjects showed significantly lower glucose utilization in the neocortex, limbic cortex, thalamus, and caudate nucleus but not in the putamen or cerebellum. After adjustment for global effects, significant reductions were still evident in the frontal, occipital, and anterior cingulate cortex, whereas the putamen and cerebellum showed significant increases.
This study, measuring the brain's metabolic response to acute receptor blockade, is a first step in the development of an assay of CNS pharmacological activity. By determining the response to neuroleptic challenge in a normal state, the study establishes a comparison group for determining response to challenge in various psychiatric conditions.
采用正电子发射断层扫描和氟脱氧葡萄糖（FDG）法，在正常、无疾病状态下测定大脑对神经阻滞剂激发的代谢反应。
对12名年轻正常男性给予5毫克氟哌啶醇，在给药前和给药后12小时进行FDG测量。将这些值与9名未接受药物干预的正常男性对照受试者的重测FDG测量值进行比较。
给予氟哌啶醇后，氟哌啶醇组受试者在新皮质、边缘叶皮质、丘脑和尾状核中的葡萄糖利用率显著降低，但在壳核或小脑中未降低。在调整整体效应后，额叶、枕叶和前扣带回皮质仍有明显的显著降低，而壳核和小脑则有显著增加。
本研究测量了大脑对急性受体阻断的代谢反应，是开发中枢神经系统药理活性测定方法的第一步。通过确定正常状态下对神经阻滞剂激发的反应，该研究建立了一个比较组，用于确定各种精神疾病状态下对激发的反应。
