Tokunaga J, Kobayashi M, Nakamura C, Kitagawa A, Arimori K, Nakano M
Department of Pharmacy, Kumamoto University Hospital, Japan.
Ren Fail. 1996 Mar;18(2):225-40. doi: 10.3109/08860229609052792.
Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 days after cisplatin injection to weigh the kidney and liver, and to determine blood urea nitrogen (BUN) and serum creatinine (serum Cr) levels. Preliminary results suggest that treatment with BP is an effective means of protection against cisplatin-induced nephrotoxicity. Combination with BP reduced the weight loss following treatment with cisplatin. The ratios of the kidney and liver weights to the body weight in the animals treated with cisplatin followed later with BP are significantly different (p < 0.05) from those in the animals that received only cisplatin. The BUN and serum Cr levels in the animals treated with cisplatin followed from -1 to 4 hr, and from -4 to 4 hr later with 250 mg/kg BP dose and followed 1 hr later with from 250 to 1000 mg/kg, and from 250 to 2000 mg/kg BP doses differed significantly (p < 0.05) from those in the animals that received only cisplatin. Histological analysis of the kidneys confirmed the protective effect of BP.
对一系列N-酰基氨基酸之一的N-苯甲酰基-β-丙氨酸（倍他米松，BP）针对顺铂诱导的肾毒性的预防作用进行了研究。雄性Wistar大鼠腹腔注射6mg/kg顺铂，并在不同时间给予不同剂量的腹腔BP。在顺铂注射后5天处死大鼠，以称量肾脏和肝脏重量，并测定血尿素氮（BUN）和血清肌酐（血清Cr）水平。初步结果表明，BP治疗是预防顺铂诱导的肾毒性的有效手段。与BP联合使用可减少顺铂治疗后的体重减轻。先接受顺铂治疗随后接受BP治疗的动物的肾脏和肝脏重量与体重之比与仅接受顺铂治疗的动物相比有显著差异（p<0.05）。在-1至4小时以及-4至4小时后给予250mg/kg BP剂量，随后1小时给予250至1000mg/kg以及250至2000mg/kg BP剂量治疗的动物的BUN和血清Cr水平与仅接受顺铂治疗的动物相比有显著差异（p<0.05）。肾脏的组织学分析证实了BP的保护作用。
