Tokunaga J, Kobayashi M, Nakamura C, Kitagawa A, Arimori K, Nakano M
Department of Pharmaceutical Services Kumamoto University Hospital, Japan.
Ren Fail. 1997 May;19(3):425-38. doi: 10.3109/08860229709047728.
Protective effects of betamipron (BP, N-benzoyl-beta-alanine), one of a series of N-acyl amino acids, on cisplatin-induced nephrotoxicity were examined. Since the damage observed in the kidney is localized to the proximal tubule cells, we investigated the influence of BP on urinary enzymes and excreta. Male Wistar rats and ddY mice were injected i.p. with 6 mg/kg and 16 mg/kg, respectively, of cisplatin combined with an i.p. 250 mg/kg BP dose. The toxicity of cisplatin as indicated by body weight gain, blood urea nitrogen, and serum creatinine levels was significantly (p < 0.05) suppressed by administration of BP after cisplatin treatment. The increase in urinary N-acetyl-beta-D-glucosaminidase activity, increase and subsequent decrease in gamma-glutamyl transferase activities, and increase in beta 2-microglobulin level observed after treatment with cisplatin were suppressed by administration of BP after cisplatin treatment. The combination of cisplatin and BP had no apparent effect on the efficacy of cisplatin against P388 leukemic cells in mice.
研究了一系列N-酰基氨基酸之一的倍他米隆（BP，N-苯甲酰基-β-丙氨酸）对顺铂诱导的肾毒性的保护作用。由于观察到的肾脏损伤局限于近端小管细胞，我们研究了BP对尿酶和排泄物的影响。雄性Wistar大鼠和ddY小鼠分别腹腔注射6mg/kg和顺铂，同时腹腔注射250mg/kg的BP剂量。顺铂治疗后给予BP，顺铂的毒性（以体重增加、血尿素氮和血清肌酐水平表示）显著（p<0.05）受到抑制。顺铂治疗后给予BP可抑制顺铂治疗后观察到的尿N-乙酰-β-D-氨基葡萄糖苷酶活性增加、γ-谷氨酰转移酶活性先增加后降低以及β2-微球蛋白水平升高。顺铂和BP的组合对顺铂对小鼠P388白血病细胞的疗效没有明显影响。
