Nishihara K, Shimizu T, Kotaki H, Sawada Y, Okuno T, Kaga K, Murofushi T, Iga T
Department of Pharmacy, Faculty of Medicine, University of Tokyo Hospital, Japan.
Antimicrob Agents Chemother. 1996 May;40(5):1098-103. doi: 10.1128/AAC.40.5.1098.
The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (22 days) intramuscular administrations of VCM (200 mg/kg of body weight) alone and GM (50 mg/kg) alone were not significantly different from those after combined administration of VCM (200 mg/kg) and GM (50 mg/kg). There was no change in the penetration ratio of VCM and GM into perilymph between administration of VCM or GM alone and the combination of both drugs. Furthermore, the hearing threshold of guinea pigs was not affected by VCM or GM alone or the combination of both drugs within the range of therapeutic VCM and GM levels in plasma in humans.
研究了雄性豚鼠单次和多次给药后万古霉素（VCM）和庆大霉素（GM）在血浆和外淋巴中的分布情况，以及单独多次给予VCM或GM以及两种药物联合使用对听觉功能的影响。单独单次和多次（22天）肌肉注射VCM（200mg/kg体重）和GM（50mg/kg）后，从血浆药物浓度-时间数据获得的VCM和GM的药代动力学参数与联合给予VCM（200mg/kg）和GM（50mg/kg）后的参数无显著差异。单独给予VCM或GM以及两种药物联合使用时，VCM和GM在外淋巴中的渗透比没有变化。此外，在人体血浆中VCM和GM治疗水平范围内，豚鼠的听力阈值不受单独使用VCM或GM或两种药物联合使用的影响。
