Xu M, Fan Y, Gao Z, Chen J, Li J
Department of Otolaryngology, Second Affiliated Hospital, Xi'an Medical University, China.
ORL J Otorhinolaryngol Relat Spec. 1995 Sep-Oct;57(5):245-9. doi: 10.1159/000276751.
Fe2+ and Zn2+ levels in perilymph of guinea pigs injected with gentamicin (GM) were examined and compared with the corresponding concentrations in CSF, serum and hairs. We observed a preventive and therapeutic action of sea buckthorn oil and injectio gastrodini to hearing loss. The results showed that: (1) the Fe2+ content in GM-injected guinea pigs was increased in perilymph and hairs; it was decreased after prevention and treatment, but there was no obvious change in CSF and serum; (2) the Zn2+ content in perilymph and CSF was increased in GM-injected guinea pigs. It rose further after prevention, but in serum and hairs it decreased. The results indicate that the ototoxic reaction to GM is related to the rise of the Fe2+ content in perilymph. The elevation of Zn2+ is a compensatory reaction. The changes in the chemical composition of perilymph are more important than those in CSF, serum and hairs for pathological changes of the cochlea. Sea buckthorn oil can prevent GM ototoxicity.
检测了注射庆大霉素（GM）的豚鼠外淋巴液中的Fe2+和Zn2+水平，并与脑脊液、血清和毛发中的相应浓度进行了比较。我们观察到沙棘油和天麻注射液对听力损失有预防和治疗作用。结果表明：（1）注射GM的豚鼠外淋巴液和毛发中的Fe2+含量增加；预防和治疗后降低，但脑脊液和血清中无明显变化；（2）注射GM的豚鼠外淋巴液和脑脊液中的Zn2+含量增加。预防后进一步升高，但血清和毛发中的Zn2+含量降低。结果表明，对GM的耳毒性反应与外淋巴液中Fe2+含量的升高有关。Zn2+升高是一种代偿反应。外淋巴液化学成分的变化对耳蜗病理变化比脑脊液、血清和毛发中的变化更重要。沙棘油可以预防GM的耳毒性。
