阿片类物质对大鼠高反应性支气管中胆碱能神经传递的异常调节。
Abnormal modulation of cholinergic neurotransmission by opioid in hyperresponsive bronchus of rats.
作者信息
Misawa M, Sato J, Furukawa Y, Chiba Y, Hosokawa T
机构信息
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
出版信息
Gen Pharmacol. 1996 Apr;27(3):441-4. doi: 10.1016/0306-3623(95)02056-x.
PMID:8723522
Abstract
- The electrical field stimulation (EFS)-induced bronchoconstriction in vitro in rats challenged by DNP-Ascaris antigen was significantly greater than that in normal rats. 2. Morphine inhibited the EFS-induced bronchoconstriction in normal rats. Whereas the inhibition of EFS-induced bronchoconstriction by the opioid was little, if any, in the DNP-Ascaris-challenged rats. 3. These findings suggest that dysfunction of presynaptic inhibitory modulation through the opioid receptor may take place in the airways of DNP-Ascaris-challenged rats.
摘要
- 在经二硝基苯-蛔虫抗原攻击的大鼠中，电场刺激（EFS）诱导的体外支气管收缩明显大于正常大鼠。2. 吗啡可抑制正常大鼠中EFS诱导的支气管收缩。而在经二硝基苯-蛔虫抗原攻击的大鼠中，阿片类药物对EFS诱导的支气管收缩几乎没有抑制作用。3. 这些发现表明，在经二硝基苯-蛔虫抗原攻击的大鼠气道中可能发生通过阿片受体的突触前抑制调节功能障碍。
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