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在链脲佐菌素诱导的糖尿病大鼠中，脑室内注射吗啡的抗伤害感受作用降低与脊髓中5-羟色胺释放减少相关。

The reduction of antinociceptive effect of morphine administered intraventricularly is correlated with the decrease of serotonin release from the spinal cord in streptozotocin-induced diabetic rats.

作者信息

Suh H W, Song D K, Wie M B, Jung J S, Hong H E, Choi S R, Kim Y H

机构信息

Department of Pharmacology, College of Medicine, Hallym University, Chunchon, Kwangwon-Do, S. Korea.

出版信息

Gen Pharmacol. 1996 Apr;27(3):445-50. doi: 10.1016/0306-3623(95)02059-4.

DOI:10.1016/0306-3623(95)02059-4
PMID:8723523
Abstract
  1. The antinociceptive effect of morphine (25 micrograms) administered into the 3rd ventricle was significantly attenuated in streptozotocin-induced diabetic rats as measured by the tail-flick assay. 2. The release of serotonin (5-HT; 5-hydroxytryptamine) from the spinal cord caused by intraventricular injection of morphine (25 micrograms) was significantly reduced in streptozotocin-induced diabetic rats. 3. No differences of 5-HT contents of the spinal cord (lumbar cord) between streptozotocin-induced diabetic- and vehicle-treated rats were found. 4. It is concluded that the reduction of antinociception produced by intraventricular injection of morphine in streptozotocin-induced diabetic rats might be, at least partly, due to the decrease of 5-HT release from the spinal cord.
摘要
  1. 通过甩尾试验测定，向第三脑室注射25微克吗啡后，链脲佐菌素诱导的糖尿病大鼠的抗伤害感受作用显著减弱。2. 向脑室内注射25微克吗啡后，链脲佐菌素诱导的糖尿病大鼠脊髓中5-羟色胺（5-HT）的释放显著减少。3. 未发现链脲佐菌素诱导的糖尿病大鼠与用赋形剂处理的大鼠之间脊髓（腰髓）5-HT含量存在差异。4. 得出的结论是，链脲佐菌素诱导的糖尿病大鼠脑室内注射吗啡所产生的抗伤害感受作用降低，可能至少部分是由于脊髓中5-HT释放减少所致。

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1
The reduction of antinociceptive effect of morphine administered intraventricularly is correlated with the decrease of serotonin release from the spinal cord in streptozotocin-induced diabetic rats.在链脲佐菌素诱导的糖尿病大鼠中，脑室内注射吗啡的抗伤害感受作用降低与脊髓中5-羟色胺释放减少相关。
Gen Pharmacol. 1996 Apr;27(3):445-50. doi: 10.1016/0306-3623(95)02059-4.
2
Effects of intraventricular injection of morphine and beta-endorphin on serotonin release from the spinal cord in rats.
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Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptors in the spinal cord.脑室内注射吗啡通过激活脊髓中的5-羟色胺3受体，引起γ-氨基丁酸释放，从而产生抗伤害感受作用。
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Modulations of spinal serotonin activity affect the development of morphine tolerance.脊髓5-羟色胺活性的调节影响吗啡耐受性的发展。
Anesth Analg. 2001 Jun;92(6):1563-8. doi: 10.1097/00000539-200106000-00043.
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Morphine tolerance in arthritic rats and serotonergic system.关节炎大鼠的吗啡耐受性与血清素能系统
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Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.链脲佐菌素诱导的糖尿病选择性降低由μ1阿片受体介导的抗伤害感受，但不降低由μ2阿片受体介导的抗伤害感受。
Neurosci Lett. 1994 Jan 3;165(1-2):141-3. doi: 10.1016/0304-3940(94)90729-3.
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Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats.吗啡的抗伤害感受作用而非μ阿片受体数量在糖尿病大鼠脊髓中减弱。
Anesthesiology. 2003 Dec;99(6):1409-14. doi: 10.1097/00000542-200312000-00026.
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The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.通过减少脊髓传入驱动可防止神经结扎损伤大鼠脊髓吗啡的抗伤害感受效能丧失。
Neurosci Lett. 1995 Oct 20;199(2):87-90. doi: 10.1016/0304-3940(95)12022-v.
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Intrathecal coadministration of serotonin and morphine differentially modulates the tail-flick reflex of intact and spinal rats.鞘内联合给予5-羟色胺和吗啡对完整大鼠和脊髓大鼠的甩尾反射有不同的调节作用。
Pharmacol Biochem Behav. 1993 Aug;45(4):871-9. doi: 10.1016/0091-3057(93)90134-f.
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Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.一氧化氮-谷氨酸级联反应调节吗啡脊髓镇痛作用的证据：大鼠行为学和微透析研究
Brain Res. 2003 Nov 14;990(1-2):77-86. doi: 10.1016/s0006-8993(03)03440-1.

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