[The general principles of cellular gravisensing].

A review of the results of studies over many years into cellular mechanisms underlying gravireception in different cell types, which were carried out by the author in the laboratory during simulation of the effects of altered gravity using a clinostat and centrifuge and under the conditions of space flight. Comparative analyses of the obtained results with the published data has been performed. It was shown that besides specific features of adaptation of different cell types to altered gravity, including microgravity, there are common pathways of adaptation of the structural-functional organization of the cell to this factor. An integral molecular mechanism underlying cell gravisensing was revealed. A working hypothesis on general principles of cell gravisensing has been formulated.