Adam G, Mühler A, Spüntrup E, Neuerburg J M, Kilbinger M, Bauer H, Fücezi L, Küpper W, Günther R W
Department of Diagnostic Radiology, University of Technology Aachen, Germany.
Invest Radiol. 1996 May;31(5):267-74. doi: 10.1097/00004424-199605000-00004.
The author assess the enhancement characteristics over time of spontaneous breast tumors in dogs comparing gadopentetate dimeglumine with a new blood-pool agent (24-gadolinium [Gd]-DTPA-cascade polymer).
Eighteen dogs with spontaneous breast tumors (5 carcinomas, 4 adenomas, and 9 benign mixed-tissue tumors) underwent dynamic magnetic resonance imaging after intravenous injection of gadopentetate dimeglumine and the blood-pool agent. Signal intensity time curves were followed up to 30 minutes after injection of both agents in the same animal. A nonlinear fitting routine enabled calculation of the delivery and clearance half lives of the contrast agent kinetics in each tumor.
For gadopentetate dimeglumine, a fast signal increase was found immediately after intravenous injection, with a subsequent signal decay in all tumors. No difference was observed between the enhancement kinetics of different tumor types after gadopentetate dimeglumine application. Similar kinetics were found in benign lesions after injection of the blood-pool agent. However, in carcinomas the blood-pool agent displayed a slower delivery, delayed peak enhancement, and slower tumor tissue clearance or even a signal plateau of more than 30 minutes.
Dynamic magnetic resonance imaging of breast neoplasms using a blood-pool agent may help to better differentiate between benign and malignant lesions because it demonstrates the enlarged interstitial space and increased capillary permeability in carcinomas.
作者通过比较钆喷酸葡胺与一种新型血池造影剂（24-钆[Gd]-二乙三胺五乙酸级联聚合物），评估犬自发性乳腺肿瘤随时间的强化特征。
18只患有自发性乳腺肿瘤的犬（5例癌、4例腺瘤和9例良性混合组织肿瘤）在静脉注射钆喷酸葡胺和血池造影剂后接受动态磁共振成像。在同一只动物中，对两种造影剂注射后30分钟内的信号强度时间曲线进行随访。通过非线性拟合程序计算每种肿瘤中造影剂动力学的输送和清除半衰期。
对于钆喷酸葡胺，静脉注射后立即发现信号快速增加，随后所有肿瘤信号衰减。应用钆喷酸葡胺后，不同肿瘤类型的强化动力学未观察到差异。注射血池造影剂后，良性病变中发现类似的动力学。然而，在癌中，血池造影剂显示出较慢的输送、延迟的峰值强化以及较慢的肿瘤组织清除，甚至信号平台期超过30分钟。
使用血池造影剂对乳腺肿瘤进行动态磁共振成像可能有助于更好地区分良性和恶性病变，因为它显示了癌中扩大的间质间隙和增加的毛细血管通透性。
