Cherry P M
Corneal Laser Centre, St James' University Hospital, Leeds, England.
Ophthalmic Surg Lasers. 1996 May;27(5 Suppl):S487-92.
A minority of patients who undergo excimer laser photorefractive keratectomy are overcorrected to the extent that they are symptomatic; they tend to be "poor healers" with little post-excimer subepithelial haze and a thinned epithelial layer. The reverse situation can also occur where "aggressive healing" results in undercorrection, excessive haze and a thickened epithelial layer.
Overcorrection was treated in 19 eyes by removal of the corneal epithelium overlying the treated cornea with a disposable number 15 scalpel blade under topical anesthesia at the slit lamp. The exposed stroma was gently abraded with the blade in order to create inflammation and the laying down of tissue to partially resteepen the cornea. Eight eyes with undercorrection had "hyperplastic epithelium" removed with the number 15 blade. The intention was to abrade underlying subepithelial haze only if it was felt that a plaque of "haze" could be removed by so doing; in fact, no plaques were removed and it was difficult to remove the epithelium without associated trauma to the superficial stroma.
The mean refraction of the overcorrected eyes was +2.77 diopters (D) compared with +0.68 D at 12 months post-scraping. This can be contrasted with -3.11 D prior to scraping, and -4.67 D at 12 months for the undercorrected eyes. The only difference that could be detected between the overcorrected and undercorrected eyes was that the mean pre-excimer refraction of the overcorrected patients was -5.68 D, whereas that of the undercorrected patients was -8.22 D. It was not possible to predict which overcorrected eyes would do well after scraping.
Scraping is a very effective treatment of overcorrection after photorefractive keratectomy. Scraping as a treatment of undercorrection should not be undertaken.
少数接受准分子激光屈光性角膜切削术的患者出现过度矫正,症状明显;他们往往是“愈合不良者”,准分子激光上皮下角膜雾状混浊少,上皮层薄。相反的情况也可能发生,即“过度愈合”导致矫正不足、雾状混浊过多和上皮层增厚。
19只过度矫正的眼睛在裂隙灯局部麻醉下,用一次性15号手术刀刀片刮除治疗角膜上方的角膜上皮。用刀片轻轻磨蚀暴露的基质,以产生炎症并形成组织,使角膜部分重新变陡。8只矫正不足的眼睛用15号刀片切除“增生上皮”。目的是仅在认为这样做可以去除“雾状混浊”斑块时才磨蚀下方的上皮下角膜雾状混浊;事实上,没有去除任何斑块,而且在不损伤浅层基质的情况下很难去除上皮。
过度矫正眼睛的平均屈光度在刮除后12个月为+2.77屈光度(D),而刮除前为+0.68 D。相比之下,矫正不足眼睛刮除前为-3.11 D,12个月时为-4.67 D。过度矫正和矫正不足眼睛之间唯一能检测到的差异是,过度矫正患者准分子激光术前的平均屈光度为-5.68 D,而矫正不足患者为-8.22 D。无法预测哪些过度矫正的眼睛在刮除后效果良好。
刮除是屈光性角膜切削术后过度矫正的一种非常有效的治疗方法。不应采用刮除来治疗矫正不足。