Kher R, Kalla N R
Centre for Endocrine Sciences, Sanjay Gandhi PG Institute of Medical Sciences, Lucknow, India.
Contraception. 1996 May;53(5):299-306.
This study was designed to investigate the effects of repeated high doses of an LHRH agonist on Swiss porton mouse seminiferous epithelium. Seminiferous epithelium showed more pronounced degenerative effects at the higher dose (1000 micrograms/kg wt/day) of the drug, with arrest of spermatogenesis at all stages of differentiation; effects on spermatogenesis become more evident after pachytene spermatocyte stage. The decrease in the testis-specific enzyme LDH-X is accounted for by the decrease in the number of cells of gametogenic origin. Although complete azoospermia was not observed, acute inhibition of motility of spermatozoa may account for severely decreased fertility rates after mating. However, reduced fertility rates due to decreased libido as a consequence of diminished testosterone levels cannot be discounted.
本研究旨在探讨重复高剂量促黄体生成素释放激素（LHRH）激动剂对瑞士波特努小鼠生精上皮的影响。在较高剂量（1000微克/千克体重/天）的药物作用下，生精上皮显示出更明显的退行性影响，在分化的各个阶段精子发生均停滞；在粗线期精母细胞阶段之后，对精子发生的影响变得更加明显。睾丸特异性酶乳酸脱氢酶X（LDH-X）的减少是由配子发生来源细胞数量的减少所导致的。虽然未观察到完全无精子症，但精子活力的急性抑制可能是交配后生育率严重下降的原因。然而，由于睾酮水平降低导致性欲减退而引起的生育率降低也不能忽视。
