Thompson K A, Malamud D, Storey B T
Department of Obstetrics and Gynecology, School of Medicine, University of Pennsylvania, Philadelphia, USA.
Contraception. 1996 May;53(5):313-8.
The broad-spectrum anti-microbial agent, C31G, containing an equimolar mixture of n-dodecyl-dimethylamine-N-oxide (C12-N-O) and N-(n-dodecyl), N-dimethyl-glycine (C12-betaine), was tested for spermicidal activity in comparison with the currently used spermicide, nonoxynol-9 (N-9). The rate of sperm cell permeabilization by the spermicides, as assayed with the fluorescent probe, TO-PRO-1, increased as the cube of the C31G concentration, while the rate increase was linear with N-9 concentration. At 0.04%, the rate of sperm cell permeabilization with both spermicides is at the limit of rapid measurement. C31G diffuses through cervical mucus at a more rapid rate than does N-9. C31G has long been known to aid wound healing and reduce inflammation, whereas N-9 has been reported to induce vaginal irritation. C31G would, thus, seem to have the spermicidal efficacy, the broad range of anti-microbial activity, and the lack of inflammatory activity that is sought in the ideal vaginal spermicide.
广谱抗菌剂C31G含有等摩尔的正十二烷基二甲基氧化胺（C12-N-O）和N-（正十二烷基）-N，N-二甲基甘氨酸（C12-甜菜碱）混合物，与目前使用的杀精剂壬苯醇醚-9（N-9）相比，对其杀精活性进行了测试。用荧光探针TO-PRO-1测定，杀精剂导致精子细胞通透性增加的速率与C31G浓度的立方成正比，而与N-9浓度呈线性关系。在0.04%的浓度下，两种杀精剂导致精子细胞通透性增加的速率都处于快速测量的极限。C31G比N-9更快地扩散通过宫颈黏液。长期以来人们都知道C31G有助于伤口愈合并减轻炎症，而据报道N-9会引起阴道刺激。因此，C31G似乎具有理想阴道杀精剂所追求的杀精效力、广泛的抗菌活性以及无炎症活性。
