Spraul C W, Lim J I, Lambert S R, Grossniklaus H E
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Retina. 1996;16(2):135-8. doi: 10.1097/00006982-199616020-00009.
The authors report the clinicopathologic features of a recurrent retinoblastoma after radioactive iodine 125 (125l) plaque therapy.
The clinical and histopathologic findings of a 1-year-old boy with a recurrent retinoblastoma after 125l radioactive plaque application were reviewed. The patient's enucleated right eye was processed for routine histologic evaluation. Immunostains for glial fibrillary acid protein and S-100 protein were performed.
Examination of the enucleated eye revealed a retinal tumor composed of two populations of cells. One population consisted of poorly differentiated cells, and the second population at the base of the tumor contained well-differentiated cells with numerous fleurettes. Immunohistochemical stains were positive for glial fibrillary acid protein and S-100 protein in the well-differentiated portion of the tumor.
This case illustrates a recurrent retinoblastoma that may have arisen from radioresistant well-differentiated cells after 125l plaque therapy.
作者报告了125碘（125I）敷贴治疗后复发性视网膜母细胞瘤的临床病理特征。
回顾了一名1岁男孩在应用125I放射性敷贴后复发性视网膜母细胞瘤的临床和组织病理学表现。对患者摘除的右眼进行常规组织学评估。进行了胶质纤维酸性蛋白和S-100蛋白的免疫染色。
对摘除眼球的检查发现视网膜肿瘤由两种细胞群组成。一群由低分化细胞组成，肿瘤底部的另一群包含有大量小花样的高分化细胞。肿瘤高分化部分的免疫组织化学染色显示胶质纤维酸性蛋白和S-100蛋白呈阳性。
该病例表明，125I敷贴治疗后复发性视网膜母细胞瘤可能起源于放射抗性的高分化细胞。
