抗惊厥药对兔脉络丛摄取5-甲基四氢叶酸的影响。

Effect of anticonvulsants on the uptake of 5-methyltetrahydrofolic acid by the choroid plexus in rabbits.

Taguchi H, Abdul-Cader Z, Perry J, Reynolds E H, Chanarin I

Clin Sci Mol Med. 1977 Jul;53(1):75-80. doi: 10.1042/cs0530075.

Abstract

The isolated choroid plexus of the rabbit takes up 5-methyltetrahydrofolate from the incubation medium. 2. Other folate analogues (pteroylglutamic acid, methotrexate, 5-formyltetrahydrofolate = folinic acid) inhibited the uptake of 5-methyltetrahydrofolate. 3. The uptake of 5-methyltetrahydrofolate was inhibited by low temperature, anaerobic conditions and dinitrophenol. 4. The anticonvulsant drugs, diphenylhydantoin and phenobarbital, had no effect on 5-methyltetrahydrofolate uptake. 5. The inhibitory effect of pteroylglutamic acid on the uptake of 5-methyltetrahydrofolate by the choroid plexus may explain the effect of long-term folic acid therapy in aggravating vitamin B12 neuropathy in pernicious anaemia.

摘要

兔的离体脉络丛可从培养液中摄取5-甲基四氢叶酸。2. 其他叶酸类似物（蝶酰谷氨酸、甲氨蝶呤、5-甲酰四氢叶酸=亚叶酸）可抑制5-甲基四氢叶酸的摄取。3. 低温、无氧条件及二硝基苯酚可抑制5-甲基四氢叶酸的摄取。4. 抗惊厥药物苯妥英和苯巴比妥对5-甲基四氢叶酸的摄取无影响。5. 蝶酰谷氨酸对脉络丛摄取5-甲基四氢叶酸的抑制作用，可能解释了长期叶酸治疗加重恶性贫血中维生素B12神经病变的作用。