低海拔对红细胞糖酵解关键酶的影响。

Effect of low altitude on glycolytic key enzymes in red blood cells.

作者信息

Bashir N A

机构信息

Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

Aviat Space Environ Med. 1996 May;67(5):478-9.

PMID:8725477

Abstract

METHOD

The ATP level and the activities of hexokinase (HK), phosphofructokinase-1 (PFK-1) and pyruvate kinase (PK) in red blood cells (RBC) were measured in 50 school students 6-12 yr of age in the Jordan Valley (JV) which is the lowest region below sea level in the world (low altitude: 390 m below sea level, hyperoxic and with an average daily value of 796 mmHg barometric pressure) and in 50 school students of the same age group in Irbid region (normal altitude: 600 m above sea level and with an average daily value of 600 mmHg barometric pressure). The same parameters were measured also in 40 school students at sea level.

RESULTS

A significant decrease in HK and PFK-1 activities and an increase in ATP level in the low altitude region, while no significant change in PK activity in JV-group when compared to Irbid and to the sea level control groups. Possible explanations will be discussed to interpret these observations.

摘要

方法

对约旦河谷50名6至12岁的在校学生（约旦河谷是世界上海拔最低的地区，低海拔：低于海平面390米，高氧环境，平均每日气压值为796毫米汞柱）以及伊尔比德地区50名同年龄组在校学生（正常海拔：高于海平面600米，平均每日气压值为600毫米汞柱）的红细胞中三磷酸腺苷（ATP）水平、己糖激酶（HK）、磷酸果糖激酶-1（PFK-1）和丙酮酸激酶（PK）的活性进行了测量。同时也对40名海平面的在校学生进行了相同参数的测量。