Yamamoto M, Hibi H, Katsuno S, Miyake K
Department of Urology, Nagoya University School of Medicine.
Nagoya J Med Sci. 1995 Dec;58(3-4):127-32.
Because the treatment of a varicocele in adolescents remains controversial, we undertook a prospective study in 51 male adolescents, aged 15-21 years, who were referred for a varicocele. Twenty-nine patients were treated with high retroperitoneal ligation of the left spermatic vein, and 22 were untreated. Eighteen healthy adolescent volunteers without a varicocele were also assessed. Testicular volume was measured using an orchiometer, and semen analyses were carried out at referral and after 1 year of follow-up. In addition, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were estimated by radioimmunoassay. Both patient groups had significantly smaller testis volumes than the controls at the outset. In the follow-up, the treated patients had testis volumes similar to those of the controls. Both testes increased significantly in volume after treatment. Although semen parameters were comparable in all groups initially, sperm concentration increased significantly after treatment of the varicocele. We concluded that varicocele treatment in adolescents leads to increased testis volume and a higher sperm concentration; however, whether early treatment will improve testicular function remains to be elucidated.
由于青少年精索静脉曲张的治疗仍存在争议，我们对51名年龄在15至21岁、因精索静脉曲张前来就诊的男性青少年进行了一项前瞻性研究。29例患者接受了左精索静脉高位腹膜后结扎术，22例未接受治疗。还评估了18名无精索静脉曲张的健康青少年志愿者。使用睾丸测量仪测量睾丸体积，并在初诊时和随访1年后进行精液分析。此外，通过放射免疫测定法估计血清促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮水平。两组患者最初的睾丸体积均明显小于对照组。在随访中，接受治疗的患者睾丸体积与对照组相似。治疗后双侧睾丸体积均显著增加。虽然所有组的精液参数最初相当，但精索静脉曲张治疗后精子浓度显著增加。我们得出结论，青少年精索静脉曲张治疗可导致睾丸体积增大和精子浓度升高；然而，早期治疗是否会改善睾丸功能仍有待阐明。
