Follow-up of a familial translocation t(10;16) with an unusual segregation pattern.
作者信息
Resta R G, Luthardt F, Kapur R
机构信息
Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98114-0999, USA.
出版信息
Am J Med Genet. 1996 May 17;63(2):363-5. doi: 10.1002/(SICI)1096-8628(19960517)63:2<363::AID-AJMG7>3.0.CO;2-U.
Abstract
Bofinger et al. [Am J Med Genet 38:1-8, 1991] reported on a four-generation family with an unusual segregation pattern involving a translocation t(10;16)(q26.3;p13.1). All relatives either had a balanced or unbalanced translocation. We report on five additional relatives, none of whom have a normal karyotype. This unusual segregation pattern may be due to chance or be the result of meiotic drive.
摘要
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