Ward D A
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
Am J Vet Res. 1996 Jun;57(6):875-8.
To compare the relative efficacies of 4 topical nonsteroidal anti-inflammatory drugs at preventing blood-aqueous barrier (BAB) disruption in dogs.
1 eye of each dog was treated with 1% suspensions of diclofenac, flurbiprofen, suprofen, or tolmetin, or with control solution. After 4 applications of eyedrops at 10-minute intervals, BAB disruption was induced in the treated eye by anterior chamber paracentesis. The severity of BAB disruption was measured by anterior chamber fluorophotometry.
40 ocular-normal dogs.
After pretreatment with eyedrops, rapid 100-microliters nonleaking anterior chamber paracentesis was performed in 1 eye of each dog to induce BAB disruption. 1 day after paracentesis, 1 ml of 10% fluorescein sodium was injected i.v.. The amount of fluorescein entering the anterior chamber of each eye was measured 30 to 60 minutes later by use of a computerized scanning fluorophotometer. The degree of BAB disruption was determined by comparing the amount of fluorescein entering the aqueous humor of the paracentesed eye with that of the nonparacentesed eye.
At postparacentesis day 1, the order of statistically significant BAB-stabilizing efficacy among groups was: diclofenac > flurbiprofen > suprofen > tolmetin = control solution.
Topically applied 1% suspensions of diclofenac, flurbiprofen, and suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. 1% tolmetin is no more effective than control solution.
比较4种局部用非甾体抗炎药预防犬血-房水屏障（BAB）破坏的相对疗效。
给每只犬的1只眼分别用双氯芬酸、氟比洛芬、舒洛芬或托美丁的1%混悬液或对照溶液治疗。每隔10分钟滴眼4次后，通过前房穿刺术诱导治疗眼的BAB破坏。通过前房荧光光度法测量BAB破坏的严重程度。
40只眼部正常的犬。
用滴眼液预处理后，对每只犬的1只眼进行快速100微升无渗漏的前房穿刺术以诱导BAB破坏。穿刺术后1天，静脉注射1毫升10%荧光素钠。30至60分钟后，使用计算机扫描荧光光度计测量进入每只眼前房的荧光素量。通过比较进入穿刺眼房水的荧光素量与未穿刺眼的荧光素量来确定BAB破坏的程度。
在穿刺术后第1天，各组间具有统计学显著意义的BAB稳定疗效顺序为：双氯芬酸>氟比洛芬>舒洛芬>托美丁=对照溶液。
局部应用双氯芬酸、氟比洛芬和舒洛芬的1%混悬液可有效预防犬穿刺术后的BAB破坏，表明它们在治疗前列腺素介导的眼部疾病方面具有潜在用途。1%托美丁的效果不优于对照溶液。
