Adle-Biassette H, Duyckaerts C, Wasowicz M, He Y, Fornes P, Foncin J F, Lecomte D, Hauw J J
Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpêtrière, Paris, France.
Neurobiol Aging. 1996 May-Jun;17(3):415-9. doi: 10.1016/0197-4580(96)00029-2.
Head trauma is considered to be a risk factor for Alzheimer's disease, because a high prevalence of beta AP deposits has repeatedly been reported in patients who died within a few days following head injury. To evaluate this statement, we undertook two studies using immunohistochemistry for beta AP and found a surprisingly low prevalence of beta AP diffuse deposits. We first selected 23 patients aged 17-63 years, who died 0-76 days after head trauma. Using beta AP antibody at the usual dilution (1:100), we did not find any deposits. With a high concentration of antibody (dilution 1:2) we found beta AP diffuse deposits in one 46-year-old case. In a second study, 17 patients aged 60-79 years old, who died 1-35 days after head injury, were compared to a control group. We did not find any significant difference in the density of beta AP diffuse deposits between cases and controls using usual dilutions of beta AP antibody. The density of beta AP diffuse deposits was linked only to aging and the presence of senile plaques.
头部创伤被认为是阿尔茨海默病的一个风险因素，因为在头部受伤后几天内死亡的患者中，β淀粉样蛋白（beta AP）沉积物的高患病率屡有报道。为了评估这一说法，我们进行了两项使用β淀粉样蛋白免疫组织化学的研究，结果发现β淀粉样蛋白弥漫性沉积物的患病率出奇的低。我们首先选择了23名年龄在17至63岁之间的患者，他们在头部创伤后0至76天死亡。使用通常稀释度（1:100）的β淀粉样蛋白抗体，我们未发现任何沉积物。使用高浓度抗体（稀释度1:2）时，我们在一名46岁的病例中发现了β淀粉样蛋白弥漫性沉积物。在第二项研究中，将17名年龄在60至79岁之间、在头部受伤后1至35天死亡的患者与一个对照组进行了比较。使用β淀粉样蛋白抗体的通常稀释度时，我们未发现病例组和对照组之间β淀粉样蛋白弥漫性沉积物密度有任何显著差异。β淀粉样蛋白弥漫性沉积物的密度仅与衰老和老年斑的存在有关。
