Iizuka T, Shoji M, Harigaya Y, Kawarabayashi T, Watanabe M, Kanai M, Hirai S
Department of Neurology, Gunma University School of Medicine, Maebashi, Japan.
Brain Res. 1995 Dec 8;702(1-2):275-8. doi: 10.1016/0006-8993(95)01163-2.
The distribution of amyloid beta-protein ending at 40 (A beta 40), 42 (A beta 42), and 43 (A beta 43) were immunocytochemically examined in Alzheimer's brains. A large number of diffuse plaques were stained with A beta 42 antibody (S42), but some were weakly labeled with A beta 43 antibody (S43). Immature and mature plaques were labeled with A beta 40 antibody (S40), S42, and S43. Thus, A beta 42 is the major component of diffuse plaques, the initial phase of plaque formation, and A beta 43 is present as a minor component. Only A beta 40 is present in cerebrovascular amyloid.
在阿尔茨海默病患者的大脑中，采用免疫细胞化学方法检测了淀粉样β蛋白40（Aβ40）、42（Aβ42）和43（Aβ43）的分布情况。大量弥漫性斑块被Aβ42抗体（S42）染色，但有些仅被Aβ43抗体（S43）弱阳性标记。未成熟和成熟斑块均被Aβ40抗体（S40）、S42和S43标记。因此，Aβ42是弥漫性斑块（即斑块形成的初始阶段）的主要成分，而Aβ43则作为次要成分存在。仅Aβ40存在于脑血管淀粉样蛋白中。
