Borst J, Jacobs H, Brouns G
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Curr Opin Immunol. 1996 Apr;8(2):181-90. doi: 10.1016/s0952-7915(96)80056-2.
The precursor T-cell receptors (TCRs) and B-cell receptors (BCRs) direct lymphocyte development to the mature T-cell and B-cell stage, respectively. Recent genetic and biochemical experiments reveal the striking parallel in structure and function of these receptors. They consist of TCR beta and BCR mu chains paired with surrogate TCR alpha and BCR light chains. Both receptors employ a two-component signal transduction unit: CD3 gamma epsilon for the pre-TCR, and CD79ab for the pre-BCR. Plasma membrane levels of pre-TCR/BCR complexes are kept extremely low, most probably by a mechanism involving specific retention in the endoplasmic reticulum. This mechanism may control the signalling activity of pre-TCR/BCR and therewith the lymphocyte differentiation process.
前体T细胞受体（TCR）和B细胞受体（BCR）分别将淋巴细胞发育引导至成熟T细胞和B细胞阶段。最近的遗传学和生物化学实验揭示了这些受体在结构和功能上的显著相似之处。它们由与替代TCRα链和BCR轻链配对的TCRβ链和BCRμ链组成。两种受体都采用双组分信号转导单元：前TCR的CD3γε，以及前BCR的CD79ab。前TCR/BCR复合物的质膜水平保持极低，很可能是通过一种涉及在内质网中特异性滞留的机制。这种机制可能控制前TCR/BCR的信号活性，从而控制淋巴细胞分化过程。
