Bireland M L, Monroe J G
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Crit Rev Immunol. 1997;17(3-4):353-85. doi: 10.1615/critrevimmunol.v17.i3-4.50.
The function of the surface antigen receptor of B cells (BCR) has been extensively studied with respect to the activation of mature B lymphocytes. B cells at other points of development (e.g., pre-B cells, immature B cells, and germinal center B cells) also express forms of the BCR, and for cells at these developmental timepoints, signaling through the BCR in some cases may lead to outcomes other than B-cell activation. Understanding the molecular events that are initiated by BCR crosslinking would enhance our understanding of the regulation and functional results of BCR signaling throughout B-cell development. In this article we review the current understanding of BCR signal transduction from initiation of the signal through changes in expression of genes that regulate the activation state. Costimulatory and modulatory molecules are considered with regard to their ability to affect the sensitivity or outcome of the BCR signal. Finally, we discuss how BCR signal transduction and the results of BCR signaling may differ at distinct stages in B-cell development.
关于成熟B淋巴细胞的激活，人们已对B细胞表面抗原受体（BCR）的功能进行了广泛研究。处于其他发育阶段的B细胞（如前B细胞、未成熟B细胞和生发中心B细胞）也表达BCR的不同形式，对于这些处于发育时间点的细胞而言，在某些情况下通过BCR进行信号传导可能会导致除B细胞激活以外的其他结果。了解由BCR交联引发的分子事件，将增进我们对整个B细胞发育过程中BCR信号传导的调控及功能结果的理解。在本文中，我们回顾了目前对BCR信号转导的认识，从信号起始到调控激活状态的基因表达变化。我们还讨论了共刺激分子和调节分子影响BCR信号敏感性或结果的能力。最后，我们探讨了在B细胞发育的不同阶段BCR信号转导及BCR信号传导结果可能存在的差异。
