免疫球蛋白基因体细胞超突变的分子基础。
The molecular basis of somatic hypermutation of immunoglobulin genes.
作者信息
Storb U
机构信息
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA.
出版信息
Curr Opin Immunol. 1996 Apr;8(2):206-14. doi: 10.1016/s0952-7915(96)80059-8.
PMID:8725944
Abstract
Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.
摘要
体细胞高频突变可扩增免疫球蛋白基因的可变区库。最近的实验证据揭示了体细胞高频突变的各种分子模型。体细胞高频突变与转录偶联DNA修复之间的联系正在形成。
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