Zúñiga-Pflücker J C, Lenardo M J
Department of Immunology, University of Toronto, Ontario, Canada.
Curr Opin Immunol. 1996 Apr;8(2):215-24. doi: 10.1016/s0952-7915(96)80060-4.
T lymphocytes differentiate from hematopoietic stem cells that settle in the microenvironment of the thymus. The earliest stages of mouse alpha/beta T-cell differentiation occurring before surface expression of the TCR include three important events: proliferation, commitment to the T lineage, and rearrangement and expression of the TCR loci. Recent evidence suggests that the survival as well as differentiation of early thymocytes depends critically on molecular signals such as those generated by the recently described pre-TCR complex.
T淋巴细胞由定居于胸腺微环境中的造血干细胞分化而来。在TCR表面表达之前，小鼠α/β T细胞分化的最早阶段包括三个重要事件：增殖、向T细胞谱系的定向分化以及TCR基因座的重排和表达。最近的证据表明，早期胸腺细胞的存活和分化关键取决于分子信号，比如最近描述的前TCR复合体所产生的信号。
