Cellarius Y G, Semenova L A
Cor Vasa. 1977;19(1):28-34.
Animal experiments have proved that the earliest morphological manifestations of acute lesions of myocardial cells (at the optical microscopic level) are myofibrillar changes detectable by polarized-light microscopy. As basic types of myocardial cell lesions there can be distinguished segmental and subsegmental contractures, intracellular myocytolysis, and primary granular disintegration. These changes persist in animal myocardium for many hours and thus can be recognized at autopsy. The application of polarized-light microscopy makes possible a diagnosis of early stages of myocardial infarction, associated with lesions of myocardial cells appearing at the periphery of the ischaemic zone already within the first minutes, revelation of focal metabolic changes leading to acute heart failure, and diagnosis of ventricular fibrillation, characterized by subsegmental contractures of the subepicardial and subendocardial layers of the myocardium.
动物实验证明，心肌细胞急性病变最早的形态学表现（在光学显微镜水平）是偏振光显微镜可检测到的肌原纤维变化。作为心肌细胞病变的基本类型，可以区分节段性和亚节段性挛缩、细胞内肌细胞溶解和原发性颗粒崩解。这些变化在动物心肌中持续数小时，因此可在尸检时识别。偏振光显微镜的应用使得诊断心肌梗死的早期阶段成为可能，这些早期阶段与缺血区周边在最初几分钟内就出现的心肌细胞病变相关，揭示导致急性心力衰竭的局灶性代谢变化，以及诊断以心肌心外膜下层和心内膜下层亚节段性挛缩为特征的心室颤动。
