Matsui K, Goldman L, Johnson P A, Kuntz K M, Cook E F, Lee T H
Department Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
J Gen Intern Med. 1996 May;11(5):262-8. doi: 10.1007/BF02598265.
To determine whether comorbid medical conditions as measured with the Charlson Comorbidity Index are independent correlates of length of stay after adjusting for other clinical and socioeconomic data.
Prospective cohort study.
Urban teaching hospital.
All 1,261 patient aged 30 years or more who were admitted to this hospital after coming to the emergency department with acute chest pain between October 1990 and May 1992.
Clinical data including comorbid medical conditions used in the Charlson index were prospectively recorded by the evaluating physician at the time of admission or by a research nurse who was blinded to the subsequent events. History of myocardial infarction was excluded from the calculation of the Charlson index score. Charlson index scores were 0 to 1 for 921 patients (73%), 2 to 3 for 263 (21%), and greater than 3 for 77 (6%). Unadjusted means (+/- SD) lengths of stay in these groups were 4.4 +/- 5.2, 5.2 +/- 5.9, and 7.5 +/- 9.3 days, respectively. In multiple linear regression analysis, compared with Charlson index scores of 0 to 1, scores of 2 to 3 and greater than 3 were significant (p < .01) independent correlates of the log transformation of length of stay after adjusting for clinical data from the initial presentation and subsequent course (model R2 = .510). In an analysis restricted to the 795 patients without clinical complications, a Charlson index score greater than 3 was an independent correlate of length of stay compared with scores of 0 to 1 (p < .01). Individual comorbid conditions were not significant correlates of length of stay after controlling for Charlson index score.
In this population of patients with acute chest pain, comorbidity as measured with the Charlson index was independently associated with length of stay after adjustment for other clinical data. After adjusting for the Charlson index, no separate comorbid condition was significantly correlated with length of stay. These findings suggest that the Charlson index can be used to adjust for comorbidities in analyses of length of stay for patients with this condition.
在对其他临床和社会经济数据进行校正后,确定用查尔森合并症指数衡量的合并症是否为住院时间的独立相关因素。
前瞻性队列研究。
城市教学医院。
1990年10月至1992年5月期间因急性胸痛到急诊科就诊后入住本院的所有1261例年龄在30岁及以上的患者。
评估医师在入院时或对后续事件不知情的研究护士前瞻性记录临床数据,包括查尔森指数中使用的合并症。心肌梗死病史被排除在查尔森指数评分计算之外。921例患者(73%)的查尔森指数评分为0至1,263例(21%)为2至3,77例(6%)大于3。这些组未校正的平均住院时间(±标准差)分别为4.4±5.2天、5.2±5.9天和7.5±9.3天。在多元线性回归分析中,与查尔森指数评分为0至1相比,在对初始表现和后续病程的临床数据进行校正后,评分为2至3和大于3是住院时间对数转换的显著(p < 0.01)独立相关因素(模型R2 = 0.510)。在一项仅限于795例无临床并发症患者的分析中,与评分为0至1相比,查尔森指数评分大于3是住院时间的独立相关因素(p < 0.01)。在控制查尔森指数评分后,个体合并症与住院时间无显著相关性。
在这群急性胸痛患者中,校正其他临床数据后,用查尔森指数衡量的合并症与住院时间独立相关。校正查尔森指数后,没有单独的合并症与住院时间显著相关。这些发现表明,查尔森指数可用于在分析该疾病患者的住院时间时校正合并症。