嗜肝性小鼠肝炎病毒MHV - 2的三种蚀斑纯化变体在无胸腺裸鼠中的肝致病性。

Hepatitogenicity of three plaque purified variants of hepatotropic mouse hepatitis virus, MHV-2 in athymic nude mice.

作者信息

Uetsuka K, Nakayama H, Goto N

机构信息

Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

Exp Anim. 1996 Apr;45(2):183-7. doi: 10.1538/expanim.45.183.

DOI:10.1538/expanim.45.183

PMID:8726145

Abstract

Hepatitogenicity of 3 plaque purified variants of hepatotropic mouse hepatitis virus, MHV-2 were examined in athymic BALB/c-nu/nu mice up to 9 weeks post infection (9WPI). All of the MHV-2S- and MHV-2M-infected mice died with severe acute hepatitis in 3WPI. On the other hand, MHV-2L-infected mice did not die until 9WPI and showed signs of slow-developing chronic hepatitis with persistent infection under low serum virus neutralizing antibody titers. This suggests that MHV-2L-infected athymic nude mice may be useful as a new model of chronic viral hepatitis.

摘要

在无胸腺的BALB/c-nu/nu小鼠中，对嗜肝性小鼠肝炎病毒MHV-2的3个蚀斑纯化变体的致肝炎性进行了长达感染后9周（9WPI）的研究。所有感染MHV-2S和MHV-2M的小鼠在3WPI时死于严重急性肝炎。另一方面，感染MHV-2L的小鼠直到9WPI才死亡，并在低血清病毒中和抗体滴度下出现慢性肝炎缓慢发展和持续感染的迹象。这表明感染MHV-2L的无胸腺裸鼠可能作为慢性病毒性肝炎的一种新模型。