Hirigoyen M B, Prabhat A, Zhang W X, Urken M L, Weinberg H
Department of Surgery, Mt. Sinai Medical Center, New York, NY 10029, USA.
J Reconstr Microsurg. 1996 Apr;12(3):195-9. doi: 10.1055/s-2007-1006476.
The role of thrombolysis in reestablishing patency in the microcirculation following ischemia, and thereby improving the efficacy of agents attenuating reperfusion injury, such as the oxygen free radical scavenger, superoxide dismutase (SOD), was investigated in a rat model. Abdominal skin flaps were subjected to normothermic ischemia induced by complete occlusion of the pedicle for periods of 12, 13, 14, 16, 18, 20, 22, and 24 hr. In Group 1 (n = 64), all animals received flap washout using 100,000U urokinase (manual injection) followed by 7,500 IU SOD given intra-arterially immediately prior to reperfusion. Animals in Group 2 received flap washout consisting of 100,000U urokinase given via a pressurized delivery system, followed by 7,500 IU SOD. Results demonstrated a statistically significant improvement in flap survival in Group 2. The authors concluded that thrombolytic therapy may be useful in improving the delivery of agents, such as SOD, which attenuate reperfusion injury in skin flaps.
在大鼠模型中研究了溶栓在缺血后重建微循环通畅性，从而提高减轻再灌注损伤药物（如氧自由基清除剂超氧化物歧化酶（SOD））疗效方面的作用。通过完全阻断蒂部使腹部皮瓣遭受常温缺血，持续时间分别为12、13、14、16、18、20、22和24小时。在第1组（n = 64）中，所有动物在再灌注前立即经动脉给予7500 IU SOD，之前先用100000U尿激酶进行皮瓣冲洗（手动注射）。第2组动物接受由通过加压输送系统给予100000U尿激酶组成的皮瓣冲洗，随后给予7500 IU SOD。结果表明第2组皮瓣存活率有统计学意义的提高。作者得出结论，溶栓治疗可能有助于改善诸如SOD等减轻皮瓣再灌注损伤药物的递送。
