Hirigoyen M B, Prabhat A, Zhang W X, Urken M L, Weinberg H
Department of Surgery, Mount Sinai Hospital, New York, NY 10029, USA.
J Reconstr Microsurg. 1995 Mar;11(2):151-5. doi: 10.1055/s-2007-1006524.
Salvage of a free-tissue transfer, when postoperative vascular compromise is detected, depends largely upon the restoration of a patent microcirculation. The therapeutic efficacy of thrombolytics infused directly into the failing flap has been clearly demonstrated. In this experiment, the authors investigated whether the method of selective administration of urokinase to failing skin flaps in 68 Sprague-Dawley rats had any effect on flap survival. In one group of animals, postischemic flaps were perfused with 100,000 IU of urokinase given by manual injection, and via a pressurized delivery system (150 mmHg) in the other group. Flap survival was assessed at 7 days. A significantly greater survival was seen in flaps treated with urokinase by controlled pressure infusion (p < 0.01). This simple method is suggested to increase the efficacy of urokinase used in the context of flap salvage.
当检测到术后血管受损时，游离组织移植的挽救很大程度上取决于通畅微循环的恢复。直接注入失活皮瓣的溶栓剂的治疗效果已得到明确证实。在本实验中，作者研究了对68只Sprague-Dawley大鼠失活皮瓣选择性给予尿激酶的方法是否对皮瓣存活有任何影响。在一组动物中，缺血后皮瓣通过手动注射给予100,000 IU尿激酶灌注，另一组则通过加压输送系统（150 mmHg）灌注。在第7天评估皮瓣存活情况。通过控制压力灌注用尿激酶治疗的皮瓣存活率显著更高（p < 0.01）。建议这种简单方法可提高在皮瓣挽救中使用尿激酶的疗效。
