O'Hara D A, DeAngelis V, Lee H, Zedie N, Seuffert P A, Amory D W
Department of Anesthesia, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.
Pharmacotherapy. 1996 May-Jun;16(3):446-52.
This randomized, open-label study compared the investigational inhalational anesthetic sevoflurane with isoflurane in 47 healthy women undergoing elective ambulatory surgery. The women were randomized to receive either sevoflurane or isoflurane in 60% nitrous oxide-oxygen. Induction with thiopental 3-6 mg/kg was followed by vecuronium 0.1 mg/kg and fentanyl 0-200 micrograms. Duration of anesthesia, time to emergence, orientation, length of stay in the surgical unit, and hospital discharge were recorded. The emergence, length of stay, and discharge times after discontinuation of sevoflurane were 9.7 +/- 0.7, 120.6 +/- 8.0, and 244 +/- 15 minutes, respectively, and for isoflurane were 11.9 +/- 1.4, 106.8 +/- 7.1, and 282 +/- 24 minutes, respectively (NS). The isoflurane group had a higher frequency of postoperative cough. At the end of surgery, the sevoflurane group received a deeper level of anesthesia (minimum alveolar concentration 1.5 vs 1.3), however, these patients were oriented earlier (13.6 +/- 1.1 min vs 17.0 +/- 1.5 min isoflurane; p = 0.02) after discontinuation of anesthesia, although this difference is of little clinical significance.
这项随机、开放标签研究比较了新型吸入麻醉剂七氟醚与异氟醚对47名择期门诊手术健康女性的效果。这些女性被随机分配，在60%氧化亚氮-氧气中接受七氟醚或异氟醚麻醉。用3-6mg/kg硫喷妥钠诱导麻醉，随后给予0.1mg/kg维库溴铵和0-200微克芬太尼。记录麻醉持续时间、苏醒时间、定向时间、在手术科室的停留时间和出院时间。停用七氟醚后的苏醒时间、停留时间和出院时间分别为9.7±0.7、120.6±8.0和244±15分钟，而异氟醚组分别为11.9±1.4、106.8±7.1和282±24分钟（无显著性差异）。异氟醚组术后咳嗽的发生率更高。手术结束时，七氟醚组的麻醉深度更深（最低肺泡浓度为1.5 vs 1.3），然而，尽管这种差异的临床意义不大，但这些患者在停用麻醉后定向更早（七氟醚组为13.6±1.1分钟，异氟醚组为17.0±1.5分钟；p = 0.02）。
