Seitsonen Elina R J, Yli-Hankala Arvi M, Korttila Kari T
Department of Anesthesia and Intensive Care, Helsinki University Hospital, Helsinki, Finland.
J Clin Anesth. 2006 Jun;18(4):272-9. doi: 10.1016/j.jclinane.2005.12.005.
To test the hypothesis that the recovery of gynecological day-case patients is equally fast after isoflurane and sevoflurane anesthesia, when administration of the inhaled agent is adjusted by monitoring the bispectral index (BIS).
Prospective, randomized, controlled, single-blinded clinical study.
University-affiliated women's hospital.
120 adult female patients, ASA physical status I or II, scheduled for ambulatory surgery under general anesthesia.
Patients were randomized to receive either isoflurane or sevoflurane as the maintenance anesthetic. BIS values were titrated to remain between 50 and 60 during the maintenance of anesthesia by adjusting the inspired concentration of the inhaled agent. Administration of the inhaled agent was discontinued abruptly at the end of the procedure.
The times to achieving several recovery end points were recorded. The main outcome parameter was the time to home-readiness. In the postoperative care unit, sedation was evaluated with the digit-symbol substitution test. The degree of pain and nausea was evaluated on the visual analog scale.
There were no statistically significant differences in the times to home-readiness, or in any other parameters of early or intermediate recovery between the 2 groups. The degrees of sedation, pain, and nausea in the postoperative care unit were similar in the 2 groups.
Isoflurane and sevoflurane are equally acceptable maintenance anesthetics in terms of the speed and quality of recovery in gynecological ambulatory surgery patients when the dose of the inhaled agent is adjusted to achieve a BIS between 50 and 60.
检验以下假设：当通过监测脑电双频指数（BIS）来调整吸入麻醉药的给药剂量时，异氟烷和七氟烷麻醉后妇科日间手术患者的恢复速度相同。
前瞻性、随机、对照、单盲临床研究。
大学附属医院的妇产科医院。
120例成年女性患者，美国麻醉医师协会（ASA）身体状况分级为I或II级，计划在全身麻醉下行门诊手术。
患者被随机分为接受异氟烷或七氟烷作为维持麻醉药。在麻醉维持期间，通过调整吸入麻醉药的吸入浓度，将BIS值调整并维持在50至60之间。手术结束时突然停止吸入麻醉药的给药。
记录达到几个恢复终点的时间。主要结局参数是准备出院的时间。在术后护理单元，用数字符号替换试验评估镇静程度。用视觉模拟评分法评估疼痛和恶心程度。
两组在准备出院时间或早期或中期恢复的任何其他参数方面均无统计学显著差异。两组在术后护理单元的镇静、疼痛和恶心程度相似。
在妇科门诊手术患者中，当调整吸入麻醉药剂量以使BIS值在50至60之间时，就恢复速度和质量而言，异氟烷和七氟烷作为维持麻醉药同样可接受。
