Tamir A, Landau M, Brenner S
Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
Dermatology. 1996;192(3):252-4. doi: 10.1159/000246377.
Pyoderma gangrenosum is an uncommon skin disease usually treated with systemic drugs, most frequently corticosteroids. Isolated topical treatment is usually considered unsatisfactory.
To evaluate the effect of topical 1% sodium cromoglycate solution on pyoderma gangrenosum in 5 patients 25-30 years of age.
5 patients, including 2 under systemic steroid treatment, hospitalized in our department from 1992 to 1993 because of pyoderma gangrenosum, were treated with topical 1% sodium cromoglycate solution. Systemic corticosteroids were further added in 2 patients whose initial improvement was inadequate.
Initial improvement was noted in all 5 patients after 3-7 days of sodium cromoglycate treatment. Complete healing of the ulcers occurred within 5-8 weeks.
Topical treatment with sodium cromoglycate can be effective as adjunctive or sole treatment in pyoderma gangrenosum.
坏疽性脓皮病是一种罕见的皮肤病，通常采用全身用药治疗，最常用的是皮质类固醇。单独的局部治疗通常被认为效果不佳。
评估1%色甘酸钠溶液局部治疗5例25至30岁坏疽性脓皮病患者的疗效。
1992年至1993年，5例因坏疽性脓皮病入住我科的患者（其中2例正在接受全身类固醇治疗）接受了1%色甘酸钠溶液局部治疗。2例初始改善不充分的患者进一步加用了全身皮质类固醇。
色甘酸钠治疗3至7天后，所有5例患者均出现初始改善。溃疡在5至8周内完全愈合。
色甘酸钠局部治疗可作为坏疽性脓皮病的辅助治疗或单一治疗有效。
