English J C, Coots N V
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA.
Cutis. 1996 May;57(5):354-6.
Nevoid hyperkeratosis of the nipple and areola is a unique clinical entity and a diagnosis of exclusion. The patient presenting with nipple/areolar hyperkeratosis must be examined carefully for other underlying cutaneous diseases such as epidermal nevi, ichthyosis, acanthosis nigricans, Darier's disease, cutaneous T-cell lymphoma, and other chronic skin dermatitides that may be responsible for the changes. If no other clinical findings are evident, the diagnosis can be made. Although the disorder is more common in women of childbearing age, men may show nevoid changes after estrogen therapy or idiopathically. The use of topical 12 percent lactic acid lotion (Lac-Hydrin) resolves the skin changes over a six-month period.
乳头乳晕痣样角化过度症是一种独特的临床病症，需排除其他疾病后才能确诊。出现乳头/乳晕角化过度的患者必须仔细检查是否存在其他潜在的皮肤疾病，如表皮痣、鱼鳞病、黑棘皮病、毛囊角化病、皮肤T细胞淋巴瘤以及其他可能导致这些变化的慢性皮肤炎症。如果没有其他明显的临床症状，即可做出诊断。虽然这种病症在育龄女性中更为常见，但男性在接受雌激素治疗后或特发性情况下也可能出现痣样变化。使用12%的乳酸洗剂（Lac-Hydrin）可在六个月内消除皮肤病变。
