Bjarnason G A
Department of Medicine, University of Toronto, Ontano, Canada.
In Vivo. 1995 Nov-Dec;9(6):557-64.
There is increasing experimental and clinical data to suggest that the timing of chemotherapy may be important for both toxicity and response. The availability of programmable infusion pumps has made the clinical testing and application of circadian scheduling possible. This paper provides an overview regarding the current clinical data with some references to the experimental studies. Further progress in this area is dependent on a better understanding of the mechanisms involved and continued high quality clinical trials.
越来越多的实验和临床数据表明，化疗时机对于毒性和疗效可能都很重要。可编程输液泵的出现使昼夜节律给药方案的临床测试和应用成为可能。本文概述了当前的临床数据，并引用了一些实验研究。该领域的进一步进展取决于对相关机制的更好理解以及持续进行的高质量临床试验。
