Tanaka H, Koba H, Honma S, Sugaya F, Abe S
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Eur Respir J. 1996 Apr;9(4):669-72. doi: 10.1183/09031936.96.09040669.
The aim of this study was to determine the relationship between the radiological pattern of Mycoplasma pneumoniae and the level of cell-mediated immunity of the host. Computed tomographic (CT) scans of the chest and the results of the purified protein derivative (PPD) test were studied during the acute stage of infection in 54 patients with M. pneumoniae pneumonia. The CT findings were used to divide the patients into two groups: one group had a predominance of nodular opacities with a centrilobular distribution (Group N; n = 29); and the other showed a predominance of an airspace consolidation (Group C; n = 25). Forty out of 54 subjects had negative tuberculin skin tests ( < 10 mm induration). The positive rate of PPD reaction was higher in Group N (13 out of 29) compared to Group C (1 out of 25) (p = 0.0005); whilst pleural effusion appeared more frequently in Group C (10 out of 25) than in Group N (3 out of 29) (p = 0.023). There was no significant difference between Groups N and C in white blood cell and lymphocyte counts, level of antibodies to M. pneumoniae in sera, and severity of the disease. These findings suggest that the characteristics of the host cell-mediated immunity might influence the pattern of pulmonary lesions in M. pneumoniae infection.
本研究的目的是确定肺炎支原体的影像学表现与宿主细胞介导免疫水平之间的关系。对54例肺炎支原体肺炎患者在感染急性期进行了胸部计算机断层扫描（CT）及纯化蛋白衍生物（PPD）试验。根据CT表现将患者分为两组：一组以小叶中心分布的结节状阴影为主（N组，n = 29）；另一组以实变为主（C组，n = 25）。54例受试者中有40例结核菌素皮肤试验阴性（硬结< 10 mm）。N组PPD反应阳性率（29例中的13例）高于C组（25例中的1例）（p = 0.0005）；而胸腔积液在C组（25例中的10例）比N组（29例中的3例）更常见（p = 0.023）。N组和C组在白细胞和淋巴细胞计数、血清中肺炎支原体抗体水平及疾病严重程度方面无显著差异。这些发现表明，宿主细胞介导免疫的特征可能影响肺炎支原体感染时肺部病变的类型。
