Khang G, Park J B, Lee H B
Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City 52242, USA.
Biomed Mater Eng. 1996;6(1):47-66.
A new technique for the prevention of platelet adhesion on the polysulfone (PSf) porous catheter system by means of saline perfusion was investigated. Commercially available ultrafiltration PSf hollow fibers were used as porous catheter tubes. Sixty milliliter of citrated canine blood was circulated for 20 min through the annular catheter flow cell system in vitro. Platelet adhesion onto the PSf porous catheter tube decreased sharply with increased saline solution perfusion rate. From the semilogarithmic relationship between the number of adhered platelets and perfusion rate, the critical perfusion rate for preventing adhesion of platelets could be about 0.3 ml min-1 cm-2. After the surface of PSf porous tubes was modified by non-ionic surfactant coating and air plasma treatment for 20 seconds without saline perfusion, the number of adhered platelets was lower than that of the control tube. These modification methods may be more effective in the prevention of initial platelet adhesion if combined with saline perfusion.
研究了一种通过盐水灌注防止血小板粘附在聚砜（PSf）多孔导管系统上的新技术。市售的超滤PSf中空纤维用作多孔导管管。60毫升枸橼酸盐抗凝犬血在体外通过环形导管流动池系统循环20分钟。随着盐溶液灌注速率的增加，血小板在PSf多孔导管管上的粘附急剧减少。根据粘附血小板数量与灌注速率之间的半对数关系，防止血小板粘附的临界灌注速率约为0.3毫升·分钟-1·厘米-2。在不进行盐水灌注的情况下，用非离子表面活性剂涂层和空气等离子体处理PSf多孔管表面20秒后，粘附的血小板数量低于对照管。如果与盐水灌注相结合，这些改性方法在预防初始血小板粘附上可能更有效。
