Khang G, Park J B, Lee H B
Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City 52242, USA.
Biomed Mater Eng. 1996;6(2):123-34.
Using a custom-made PVC medical tube ateriovenous (A-V) shunt and a porous polysulfone (PSf) catheter, an ex vivo and in vivo experiment were carried out to study the effectiveness of saline solution perfusion to prevent adhesion of platelets without using anticoagulants. The critical perfusion rate for preventing adhesion of platelets onto the PSf catheter tubes is about 0.45 ml min-1 cm-2. The higher perfusion rate resulted in a lesser platelet adhesion. At the highest perfusion rate tested, 0.92 ml min-1 cm-2, the number of adhered platelets decreased by 98% in the in vivo experiment. From the results of ex vivo and in vivo canine experiments, the saline perfusion catheters can be used as a very useful clinical armamentarium to prevent platelet and blood cell adhesion without using anticoagulants.
使用定制的聚氯乙烯（PVC）动静脉（A-V）分流管和多孔聚砜（PSf）导管，进行了一项体外和体内实验，以研究在不使用抗凝剂的情况下，盐溶液灌注预防血小板黏附的有效性。防止血小板黏附到PSf导管上的临界灌注速率约为0.45毫升/分钟·平方厘米。较高的灌注速率导致较少的血小板黏附。在测试的最高灌注速率0.92毫升/分钟·平方厘米下，体内实验中黏附的血小板数量减少了98%。根据体外和体内犬类实验的结果，盐溶液灌注导管可作为一种非常有用的临床手段，在不使用抗凝剂的情况下预防血小板和血细胞黏附。
