Tracy S, Chapman N M, Romero J, Ramsingh A I
Dept of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA.
Trends Microbiol. 1996 May;4(5):175-9. doi: 10.1016/0966-842x(96)10026-3.
Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.
柯萨奇B组病毒（CVBs）是人类炎症性心肌病的病原体。随着柯萨奇病毒基因组感染性cDNA拷贝的出现，现在人们开始了解小鼠中柯萨奇病毒毒力表型的遗传学。迄今为止，对CVB3和CVB4的研究表明，非翻译区和衣壳蛋白中的位点可影响毒力表型。这些位点对表型表达的相对重要性仍不清楚。
