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[内皮细胞功能与血管生成]

[Endothelial cell function and angiogenesis].

作者信息

Kanayasu-Toyoda T, Morita I, Murota S

机构信息

Department of Physiological Chemistry, Tokyo Medical Dental University, Japan.

出版信息

Nihon Yakurigaku Zasshi. 1996 Mar;107(3):99-107.

PMID:8728283
Abstract

Angiogenesis, a process of new blood vessel formation, is an integral part of development, wound repair and tumor growth. The formation of capillary networks requires a complex series of cellular events, in which endothelial cells locally degrade their basement membrane, migrate into the connective tissue stroma, proliferate at the migrating tip, enlongate and organize into capillary loops. In response to angiogenic stimuli, endothelial cells in culture develop networks of capillary-like tubes. In this paper, we showed the relationship between angiogenesis and diseases, the assay systems of angiogenesis and the reports of angiogenesis published recently.

摘要

血管生成是一个新血管形成的过程,是发育、伤口修复和肿瘤生长不可或缺的一部分。毛细血管网络的形成需要一系列复杂的细胞事件,其中内皮细胞局部降解其基底膜,迁移到结缔组织基质中,在迁移的尖端增殖,伸长并组织成毛细血管环。在血管生成刺激的作用下,培养中的内皮细胞会形成毛细血管样的网络。在本文中,我们展示了血管生成与疾病之间的关系、血管生成的检测系统以及最近发表的血管生成相关报告。

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