Ren T
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506, USA.
Neurosci Lett. 1996 Apr 5;207(3):167-70. doi: 10.1016/0304-3940(96)12524-6.
In order to study the linearity of outer hair cell fast electromotility in vivo, an acoustic tone was used to interact with the electrically evoked distortion product otoacoustic emissions. Otoacoustic emissions at the primary frequencies (f1, f2, where f1 < f2) and the distortion frequencies (2f1 - f2 and f2 - f1) were evoked by a complex current, with f1 and f2 components, delivered to the gerbil round window. An externally given acoustic tone at the frequency f1 or f2 with appropriate phase and level can completely abolish both the 2f1 - f2 and f2 - f1 distortion tones. Because the external tone causes basilar membrane vibration at its natural topographic locations, this result indicates that the observed distortion tones were generated near the locations of f1 and f2 frequencies on the basilar membrane and that no distortion occurred from the stimulated cells near the electrode. The study strongly suggests a linear electromechanical transduction of the outer hair cells in the sensitive cochlea.
为了研究体内外毛细胞快速电运动的线性关系，使用纯音与电诱发的畸变产物耳声发射相互作用。通过向沙鼠圆窗施加包含f1和f2成分的复合电流，诱发初级频率（f1、f2，其中f1 < f2）和畸变频率（2f1 - f2和f2 - f1）处的耳声发射。在频率f1或f2处具有适当相位和强度的外部给定纯音可以完全消除2f1 - f2和f2 - f1畸变音。由于外部纯音在其固有拓扑位置引起基底膜振动，该结果表明观察到的畸变音是在基底膜上f1和f2频率位置附近产生的，并且在电极附近受刺激的细胞没有发生畸变。该研究强烈表明敏感耳蜗中外毛细胞的线性机电转导。
