Korte S M, Korte-Bouws G A, Koob G F, De Kloet E R, Bohus B
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
Pharmacol Biochem Behav. 1996 May;54(1):261-7. doi: 10.1016/0091-3057(95)02172-8.
The behavioral effects of intracerebroventricular (i.c.v.) administration of a specific mineralocorticoid receptor (MR) antagonist [RU28318 (10-50 ng/2 microliters)], a glucocorticoid receptor (GR) antagonist [RU38486 (1-50 ng/2 microliters)], or both antagonists (50 ng/2 microliters), were studied in two different animal models of fear and anxiety in rats. In the defensive burying paradigm simultaneous blockade of MR and GR increased immobility behavior, whereas a small decrease in defensive burying was seen. In the fear-potentiated startle test concurrent MR and GR blockade led to an increase in fear-potentiated startle at the highest loudness level (105 dB). In both tests the antagonists were not effective when given separately. The findings are discussed in terms of the involvement of GR and MR in neural mechanisms of fear and anxiety.
在大鼠恐惧和焦虑的两种不同动物模型中，研究了脑室内（i.c.v.）注射特定盐皮质激素受体（MR）拮抗剂[RU28318（10 - 50纳克/2微升）]、糖皮质激素受体（GR）拮抗剂[RU38486（1 - 50纳克/2微升）]或两种拮抗剂（50纳克/2微升）的行为效应。在防御性埋土范式中，同时阻断MR和GR会增加不动行为，而防御性埋土行为则略有减少。在恐惧增强惊吓试验中，同时阻断MR和GR会导致在最高响度水平（105分贝）时恐惧增强惊吓增加。在两项试验中，单独给予拮抗剂均无效。从GR和MR参与恐惧和焦虑的神经机制方面对这些发现进行了讨论。
