Korte S M, de Boer S F, de Kloet E R, Bohus B
Department of Animal Physiology, University of Groningen, The Netherlands.
Psychoneuroendocrinology. 1995;20(4):385-94. doi: 10.1016/0306-4530(94)00069-7.
The effects of intracerebroventricular (ICV) administration of the mineralocorticoid receptor (MR) antagonist, RU28318, and the glucocorticoid receptor (GR) antagonist, RU38486, were studied on behavior of rats exposed to a compartment previously associated with a stressor, and placed subsequently in an elevated plus-maze test. Fear-motivated immobility behavior was attenuated by the MR antagonist in a dose of 50 or 100 ng ICV, whereas the GR antagonist alone or simultaneous administration of both antagonists had no significant effect. In the elevated plus-maze, immediately after the exposure to the conditioned stressor, both the GR antagonist (50 ng) and MR antagonist (50 ng) increased the percentage of time the rats spent on open arms, and increased the amount of entries into these open arms. These data are interpretated in terms of the involvement of the GR and MR in fear and anxiety.
研究了脑室内（ICV）注射盐皮质激素受体（MR）拮抗剂RU28318和糖皮质激素受体（GR）拮抗剂RU38486对暴露于先前与应激源相关的隔室、随后进行高架十字迷宫试验的大鼠行为的影响。剂量为50或100 ng ICV的MR拮抗剂可减弱恐惧驱动的不动行为，而单独使用GR拮抗剂或同时给予两种拮抗剂均无显著影响。在高架十字迷宫中，暴露于条件应激源后立即给予GR拮抗剂（50 ng）和MR拮抗剂（50 ng），均可增加大鼠在开放臂上停留的时间百分比，并增加进入这些开放臂的次数。这些数据从GR和MR参与恐惧和焦虑的角度进行了解释。
