Buckingham J C, Loxley H D, Christian H C, Philip J G
Department of Pharmacology, Charing Cross & Westminster Medical School, London, UK.
Pharmacol Biochem Behav. 1996 May;54(1):285-98. doi: 10.1016/0091-3057(95)02127-2.
It is now well established that challenges to the immune system (e.g., infection, inflammation) initiate diverse changes in neuroendocrine function, the most overt of which is activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. The glucocorticoids that are released as a consequence fulfill a vital role in the maintenance of homeostasis that is effected in part through their ability to quench the immune/inflammatory response and thereby prevent them accelerating to a point where they become hazardous to the host. This article discusses the putative mechanisms by which immune insults stimulate the HPA axis, with particular reference to the roles and interactions of the interleukins, eicosanoids and glucocorticoids.
现已充分证实，免疫系统所面临的挑战（如感染、炎症）会引发神经内分泌功能的多种变化，其中最明显的是下丘脑 - 垂体 - 肾上腺皮质（HPA）轴的激活。由此释放的糖皮质激素在维持体内平衡方面发挥着至关重要的作用，这部分是通过它们抑制免疫/炎症反应的能力来实现的，从而防止这些反应加速到对宿主造成危害的程度。本文讨论了免疫损伤刺激HPA轴的假定机制，特别提及白细胞介素、类花生酸和糖皮质激素的作用及相互作用。
