Bodera Paweł, Stankiewicz Wanda, Kocik Janusz
Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Pharmacol Rep. 2014 Apr;66(2):288-91. doi: 10.1016/j.pharep.2013.12.003. Epub 2014 Mar 3.
Brain-immune system interactions and neurohormonal changes which are induced by psychophysiological factors are growing areas of scientific interest. Central (CNS) and autonomic nervous-endocrine-immune system pathways are connected with a number of behavioral and physiological factors which may be linked to disease susceptibility and progression.
In this paper, influence of orphanin FQ/nociceptin receptor (OFQ/N) on the hypothalamic-pituitary-adrenal (HPA) axis and their influence on the immunological system was reviewed.
The neuroendocrine system, in particular the hypothalamic-pituitary-adrenal (HPA) axis, is closely connected with the cytokines. HPA axis activation by cytokines, via the release of glucocorticoids has, in turn, been found to play a critical role in restraining and shaping immune responses. Investigation of the OFQ/N system and G-proteins suggests a role for this receptor as a down-regulator of cytokine, chemokine and chemokine receptor expression.
由心理生理因素诱导的脑-免疫系统相互作用和神经激素变化是科学研究中日益受到关注的领域。中枢神经系统（CNS）和自主神经-内分泌-免疫系统途径与许多行为和生理因素相关，这些因素可能与疾病易感性和进展有关。
本文综述了孤啡肽/痛敏肽受体（OFQ/N）对下丘脑-垂体-肾上腺（HPA）轴的影响及其对免疫系统的影响。
神经内分泌系统，尤其是下丘脑-垂体-肾上腺（HPA）轴，与细胞因子密切相关。细胞因子通过释放糖皮质激素激活HPA轴，进而在抑制和塑造免疫反应中发挥关键作用。对OFQ/N系统和G蛋白的研究表明，该受体作为细胞因子、趋化因子和趋化因子受体表达的下调因子发挥作用。
