Arruzazabala M L, Carbajal D, Mas R, Molina V, Valdes S, Laguna A
Departamento de Farmacología, Centro Nacional de Investigaciones Científicas, La Habana, Cuba.
Biol Res. 1994;27(3-4):205-8.
Policosanol is a natural mixture of higher primary aliphatic alcohols isolated and purified from sugar cane (Saccharum officinarum, L.) wax, whose main component is octacosanol. Policosanol (5-200 mg/kg) orally administered for 4 weeks to normocholesterolemic New Zealand rabbits significantly reduced total cholesterol and low density lipoprotein cholesterol (LDL-C) serum levels in a dose dependent manner. Serum triglyceride levels of treated and control animals were significantly different, but the reduction observed was not dose-dependent. High density lipoprotein cholesterol (HDL-C) levels remained unchanged. Results indicate that the reduction in total cholesterol values induced by policosanol is mainly mediated through a decrease in LDL-C levels.
聚多卡醇是从甘蔗（甘蔗属，L.）蜡中分离纯化得到的高级伯脂肪醇的天然混合物，其主要成分是二十八烷醇。给正常胆固醇水平的新西兰兔口服聚多卡醇（5-200毫克/千克），持续4周，可显著降低总胆固醇和低密度脂蛋白胆固醇（LDL-C）的血清水平，且呈剂量依赖性。治疗组和对照组动物的血清甘油三酯水平有显著差异，但观察到的降低并非剂量依赖性。高密度脂蛋白胆固醇（HDL-C）水平保持不变。结果表明，聚多卡醇引起的总胆固醇值降低主要是通过降低LDL-C水平介导的。
