Bernztein R, Grenoville M
Hospital Nacional de Pediatría J. P. Garrahan, Buenos Aires, Argentina.
Medicina (B Aires). 1995;55(4):324-8.
The objective has been to identify the different etiologies and elaborate a diagnostic and therapeutical methodology for patients with chronic cough. During one year we studied prospectively 83 patients with persistent cough of daily appearance with an evolution of four or more weeks and no previous etiologic diagnosis. We worked on three diagnostic (D) levels. D1: Based on the anamnesis and physical examination. D2: Sequential incorporation of complementary exams. D3: Evaluation of the response to the specific treatment. We divided the population into 2 groups: G1 healthy children, G2 children followed in our hospital for different conditions. The mean age was 4.7 years (range, 3 months to 15 years), and the average duration of cough was 4.9 months (range, 1 to 36 months). In G1 the following causes were identified in 78 children: cough variant asthma 41 (52%), asthma+upper respiratory tract infections 8 (10%), asthma+lower respiratory tract infections 6 (7%), postnasal drip syndrome (sinusitis, adenoiditis) 5 (6%), psychogenic 6 (7%), undetermined 4 (5%), gastroesophageal reflux 2, asthma+cigarette 2, AIDS 1, Sjogren syndrome 1, vascular ring 1, cricopharyngeal foreign body 1. In G2 out of 5 children we have found: 2 children with chronic encephalopathies who had swallowing disorders and gastroesophageal reflux, 1 patient with Down syndrome presenting hypogammaglobulinemia and bronchiectasis, 1 tracheaesophageal fistula in H in a child with recurrent pneumonia, 1 lymphocytic pneumonia in an AIDS patient. The D1 was correct in 92% of the cases. The specific therapy has proved useful for achieving the remission of the symptoms. Although asthma is the most frequent cause of chronic cough, other etiologies exist and must be ruled out.
目的是确定慢性咳嗽患者的不同病因,并制定诊断和治疗方法。在一年时间里,我们对83例每日持续咳嗽、病程达四周或更长时间且既往无病因诊断的患者进行了前瞻性研究。我们进行了三个诊断(D)级别。D1:基于病史和体格检查。D2:序贯进行辅助检查。D3:评估对特定治疗的反应。我们将研究人群分为两组:G1为健康儿童组,G2为在我院因不同疾病就诊的儿童组。平均年龄为4.7岁(范围3个月至15岁),咳嗽平均持续时间为4.9个月(范围1至36个月)。在G1组的78名儿童中确定了以下病因:咳嗽变异性哮喘41例(52%),哮喘+上呼吸道感染8例(10%),哮喘+下呼吸道感染6例(7%),鼻后滴漏综合征(鼻窦炎、腺样体炎)5例(6%)),精神性咳嗽6例(7%)),病因不明4例(5%),胃食管反流2例)),哮喘+吸烟2例))),艾滋病1例)),干燥综合征1例)),血管环1例)),环咽肌异物1例))。在G2组5名儿童中,我们发现:2例患有慢性脑病且有吞咽障碍和胃食管反流的儿童,1例患有唐氏综合征且有低丙种球蛋白血症和支气管扩张症的患者,1例患有复发性肺炎的儿童H中有气管食管瘘,1例艾滋病患者患有淋巴细胞性肺炎。D1在92%的病例中是正确的。特异性治疗已被证明有助于症状缓解。虽然哮喘是慢性咳嗽最常见的原因,但其他病因也存在,必须予以排除。