[克莱蒙费朗大学医院中心医院工作人员甲型、乙型和丙型病毒性肝炎标志物的血清流行率]

[Seroprevalence of markers of viral hepatitis A, B and C in hospital personnel at the Clermont-Ferrand University Hospital Center].

作者信息

Djeriri K, Fontana L, Laurichesse H, Peigue-Lafeuille H, Henquell C, Chamoux A, Beytout J, Catilina P, Rey M

机构信息

Service de Médecine du Travail et des Maladies professionnelles du CHU de Clermont-Ferrand.

出版信息

Presse Med. 1996 Feb 3;25(4):145-50.

PMID:8728898

Abstract

OBJECTIVES

Evaluate risk of hepatitis A, B and C infection and anti HBV vaccination policy in hospital personnel.

METHODS

A sample of 440 health care workers (7.5% of the personnel at the Clermont-Ferrand University Hospital) representing 74.5% people directly involved in health care and 25.5% other workers were selected at random and stratified by work classification and age. A questionnaire was used to establish personal data on viral hepatitis status and blood samples were drawn for serological tests.

RESULTS

Seroprevalence for hepatitis A was 52% with no significant difference between health care and other workers. For hepatitis B, 88.3% of the population had been vaccinated and anti-HBs titre was > or = 10 mIU/ml for 91.6% and > or = 50 mIU/ml for 86.1%. Seroprevalence for anti-HBc was 7% and none of the subjects were positive for HBs antigen. Anti-hepatic C antibodies were found in 2 health care workers (0.7%).

CONCLUSION

These findings emphasize the need to persue further preventive actions against hepatitis A, B and C and the requirement for continued efforts in elementary hygiene.

摘要

目的

评估医院工作人员感染甲型、乙型和丙型肝炎的风险以及乙肝疫苗接种政策。

方法

从克莱蒙费朗大学医院随机抽取440名医护人员（占医院工作人员的7.5%）作为样本，这些人员中74.5%直接参与医疗保健工作，25.5%为其他工作人员，并按工作类别和年龄进行分层。通过问卷调查获取有关病毒性肝炎状况的个人数据，并采集血样进行血清学检测。

结果

甲型肝炎血清阳性率为52%，医护人员和其他工作人员之间无显著差异。对于乙型肝炎，88.3%的人群已接种疫苗，91.6%的人群抗-HBs滴度≥10 mIU/ml，86.1%的人群抗-HBs滴度≥50 mIU/ml。抗-HBc血清阳性率为7%，所有受试者HBs抗原均为阴性。在2名医护人员（0.7%）中发现抗丙型肝炎抗体。