Zhu S, Liu S, Ge S
Burn Institute, Changhai Hospital, Shanghai.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995 Nov;11(6):430-2.
This comparative study was performed to evaluate the effects of resuscitation of burn shock with hypertonic sodium lactate dextran 70(HLD solution: Na+250 mmol/L and 6% dextran 70) and lactate Ringer' solution on cardiac function, lipid peroxide and SOD activity of heart tissue. Dogs with 35% TBSA third degree burns received, one hour postburn, either HLD resuscitation (HLD group, n = 6) in the amount of 19.6 ml.kg-1/g hours, followed by LR 6 ml.kg-1/% TBSA, or LR resuscitation (LR group, n = 6) in the amount of 8 ml.kg-1/% TBSA LR solution. The results of this experiment showed that cardiac index (CI) of HLD group was much higher than that of LR group at 4, 8, 12, 24 hours postburn. The dp/dt max and-dp/dt max of HLD group were much higher than that of LR group at 12.24 hours postburn. Level of MDA in heart tissue of HLD group (1.74 +/- 0.28 10 mol/g heart tissue) was much lower than of LR group (3.23 +/- 0.56 10 mol/g heart tissue) at 24 hours postburn (P < 0.01). Meanwhile, SOD activity in heart tissue of HLD group (157.49 +/- 32.23 u/mg heart tissue) was much higher than that of LR group (46.88 +/- 16.28 u/mg heart tissue) (P < 0.01). These results suggested that HLD resuscitation might be beneficial in improving postburn cardiac function and attenuating postburn oxidant-induced lipid peroxidation in heart tissue not only by its "oxygen scavenger" effect, but also by its elevation of SOD activity of heart tissue.
本比较研究旨在评估用高渗乳酸钠右旋糖酐70（HLD溶液：Na⁺250 mmol/L和6%右旋糖酐70）和乳酸林格氏液复苏烧伤休克对心功能、心脏组织脂质过氧化物及超氧化物歧化酶（SOD）活性的影响。35%总体表面积三度烧伤的犬只在烧伤后1小时接受以下处理：HLD复苏（HLD组，n = 6），剂量为19.6 ml·kg⁻¹/g·小时，随后给予乳酸林格氏液6 ml·kg⁻¹/%总体表面积；或乳酸林格氏液复苏（LR组，n = 6），剂量为8 ml·kg⁻¹/%总体表面积乳酸林格氏液。本实验结果显示，HLD组的心脏指数（CI）在烧伤后4、8、12、24小时均显著高于LR组。HLD组的dp/dt max和 -dp/dt max在烧伤后12、24小时显著高于LR组。烧伤后24小时，HLD组心脏组织中丙二醛（MDA）水平（1.74 ± 0.28×10⁻⁶mol/g心脏组织）显著低于LR组（3.23 ± 0.56×10⁻⁶mol/g心脏组织）（P < 0.01）。同时，HLD组心脏组织中SOD活性（157.49 ± 32.23 U/mg心脏组织）显著高于LR组（46.88 ± 16.28 U/mg心脏组织）（P < 0.01）。这些结果表明，HLD复苏可能不仅通过其“氧清除剂”作用，还通过提高心脏组织的SOD活性，有助于改善烧伤后心功能并减轻烧伤后氧化应激诱导的心脏组织脂质过氧化。
